BRAFV600E induces ABCB1/P-glycoprotein expression and drug resistance in B-cells via AP-1 activation
نویسندگان
چکیده
منابع مشابه
Homocysteine Induces Heme Oxygenase-1 Expression via Transcription Factor Nrf2 Activation in HepG2 Cells
Background: Elevated level of plasma homocysteine has been related to various diseases. Patients with hyperhomocysteinemia can develop hepatic steatosis and fibrosis. We hypothesized that oxidative stress induced by homocysteine might play an important role in pathogenesis of liver injury. Also, the cellular response designed to combat oxidative stress is primarily controlled by the transcripti...
متن کاملhomocysteine induces heme oxygenase-1 expression via transcription factor nrf2 activation in hepg2 cells
background: elevated level of plasma homocysteine has been related to various diseases. patients with hyperhomocysteinemia can develop hepatic steatosis and fibrosis. we hypothesized that oxidative stress induced by homocysteine might play an important role in pathogenesis of liver injury. also, the cellular response designed to combat oxidative stress is primarily controlled by the transcripti...
متن کاملAmyloid-beta induces Smac release via AP-1/Bim activation in cerebral endothelial cells.
Insoluble fibrils of amyloid-beta peptide (Abeta) are the major component of senile and vascular plaques found in the brains of Alzheimer's disease (AD) patients. Abeta has been implicated in neuronal and vascular degeneration because of its toxicity to neurons and endothelial cells in vitro; some of these cells die with characteristic features of apoptosis. We used primary cultures of murine c...
متن کاملB-cell receptor activation induces BIC/miR-155 expression through a conserved AP-1 element.
microRNA-155 is an oncogenic microRNA that has been shown to be critical for B-cell maturation and immunoglobulin production in response to antigen. In line with its function in B-cell activation, miR-155, and its primary transcript, B-cell integration cluster (BIC), is induced by B-cell receptor (BCR) cross-linking. Using pharmacological inhibitors in the human B-cell line, Ramos, we show that...
متن کاملInterleukin-18 induces EMMPRIN expression in primary cardiomyocytes via JNK/Sp1 signaling and MMP-9 in part via EMMPRIN and through AP-1 and NF- B activation
Venkatapuram Seenu Reddy, Sumanth D. Prabhu, Srinivas Mummidi, Anthony J. Valente, Balachandar Venkatesan, Prakashsrinivasan Shanmugam, Patrice Delafontaine, and Bysani Chandrasekar Cardiothoracic Surgery, University of Texas Health Science Center, San Antonio, Texas; Institute of Molecular Cardiology, Department of Medicine, University of Louisville, and Medical Service, Louisville Veterans Af...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Leukemia Research
سال: 2015
ISSN: 0145-2126
DOI: 10.1016/j.leukres.2015.08.017